BDBM404399 US10343992, Example 51::US10689345, Example 51::rac-(3aR,6aR)-1-([1,1'-biphenyl]- 3-carbonyl)hexahydropyrrolo[3,4- b]pyrrole-5(1H)-carbonitrile

SMILES O=C(N1CCC2CN(CC12)C#N)c1cccc(c1)-c1ccccc1

InChI Key InChIKey=PPHZJOGUKRXUKE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 404399   

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404399(rac-(3aR,6aR)-1-([1,1'-biphenyl]- 3-carbonyl)hexah...)
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2020
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404399(rac-(3aR,6aR)-1-([1,1'-biphenyl]- 3-carbonyl)hexah...)
Affinity DataIC50: 100nMAssay Description:USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent