BDBM404370 2-{(S)-3-[4-(4-Methoxy-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl}-3H-cycloheptaimidazol-4-one::USRE46942, Example 30

SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2cc3ccccc(=O)c3[nH]2)C1=O

InChI Key InChIKey=FICOSMQGCGGNKM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 404370   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Novartis

US Patent
LigandPNGBDBM404370(2-{(S)-3-[4-(4-Methoxy-benzoyl)-piperidin-1-yl]-2-...)
Affinity DataIC50: 5nMAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Novartis

US Patent
LigandPNGBDBM404370(2-{(S)-3-[4-(4-Methoxy-benzoyl)-piperidin-1-yl]-2-...)
Affinity DataIC50: 9.5nMAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent