BDBM404127 US10336717, Compound 425

SMILES CN1C(=S)NC2(C1=O)c1cc(OCC3CC3)ccc1OC21CCc2ccccc2CC1

InChI Key InChIKey=RMBVNWQLTYQLPM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 404127   

TargetBeta-secretase 1(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM404127(US10336717, Compound 425)
Affinity DataIC50: 4.10nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
Go to US Patent