BDBM402735 2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-[4- (difluoromethyl)thiophen- 3-yl]pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10329295, Example 42

SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3cscc3C(F)F)n2n1

InChI Key InChIKey=DOAPMLYBMVCNJI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402735   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402735(US10329295, Example 42 | 2-{[(1R,2S)-2- aminocyclo...)
Affinity DataIC50: 4nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
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