BDBM402337 6-(3-(2-chloro-4-((5- cyclopropyl-3-(2,6-dichloro- 4-methylphenyl)isoxazol-4- yl)methoxy)phenyl)-3- hydroxyazetidin-1-yl)-5- fluoronicotinic acid::US10329286, Example 9::US11247986, Example 9

SMILES Cc1cc(Cl)c(-c2noc(C3CC3)c2COc2ccc(c(Cl)c2)C2(O)CN(C2)c2ncc(cc2F)C(O)=O)c(Cl)c1

InChI Key InChIKey=UCQORVZNPUQUMB-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402337   

TargetBile acid receptor [187-472](Human)
Gilead Sciences

US Patent
LigandPNGBDBM402337(US10329286, Example 9 | 6-(3-(2-chloro-4-((5- cycl...)
Affinity DataEC50:  57nMAssay Description:Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
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TargetBile acid receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM402337(US10329286, Example 9 | 6-(3-(2-chloro-4-((5- cycl...)
Affinity DataEC50:  57nMAssay Description:Expression and purification of the FXR-LBD: An overnight preculture of a transformed E. coli strain was diluted 1:20 in LB-Ampicillin medium and grow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent