BDBM402336 6-(3-(2-chloro-4-((5- cyclopropyl-3-(2,6- dimethoxyphenyl)isoxazol-4- yl)methoxy)phenyl)-3- hydroxyazetidin-1-yl)-5- fluoronicotinic acid::US10329286, Example 8::US11247986, Example 8

SMILES COc1cccc(OC)c1-c1noc(C2CC2)c1COc1ccc(c(Cl)c1)C1(O)CN(C1)c1ncc(cc1F)C(O)=O

InChI Key InChIKey=JJVVPLHMDOFRRR-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 402336   

TargetBile acid receptor [187-472](Human)
Gilead Sciences

US Patent
LigandPNGBDBM402336(US10329286, Example 8 | 6-(3-(2-chloro-4-((5- cycl...)
Affinity DataEC50:  15nMAssay Description:Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
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TargetBile acid receptor(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM402336(US10329286, Example 8 | 6-(3-(2-chloro-4-((5- cycl...)
Affinity DataEC50:  593nMAssay Description:Agonist activity at FXR (unknown origin) by mammalian one hybrid assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM402336(US10329286, Example 8 | 6-(3-(2-chloro-4-((5- cycl...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at FXR (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM402336(US10329286, Example 8 | 6-(3-(2-chloro-4-((5- cycl...)
Affinity DataEC50:  15nMAssay Description:Expression and purification of the FXR-LBD: An overnight preculture of a transformed E. coli strain was diluted 1:20 in LB-Ampicillin medium and grow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent