BDBM402326 6-(3-(2-chloro-4-((5- cyclopropyl-3-(2,6- dichlorophenyl)isoxazol-4- yl)methoxy)phenyl)-3- hydroxyazetidin-1-yl)-2- methylnicotinic acid::US10329286, Example 3::US11247986, Example 3

SMILES Cc1nc(ccc1C(O)=O)N1CC(O)(C1)c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1Cl

InChI Key InChIKey=MJSWJMXAAXAIMQ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402326   

TargetBile acid receptor [187-472](Human)
Gilead Sciences

US Patent
LigandPNGBDBM402326(US10329286, Example 3 | 6-(3-(2-chloro-4-((5- cycl...)
Affinity DataEC50:  4.40nMAssay Description:Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
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TargetBile acid receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM402326(US10329286, Example 3 | 6-(3-(2-chloro-4-((5- cycl...)
Affinity DataEC50:  4.40nMAssay Description:Expression and purification of the FXR-LBD: An overnight preculture of a transformed E. coli strain was diluted 1:20 in LB-Ampicillin medium and grow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent