BDBM402196 (9aRS)-7-[2,6-difluoro-4-(2- phenylethynyl)phenyl]-2-(2,6- dimethylpyrimidin-4-yl)-9a- methyl-4,9-dihydro-3H- pyrazino[1,2-c]pyrimidine- 1,6,8-trione::US10011607, 29

SMILES Cc1cc(nc(C)n1)N1CCN2C(=O)N(C(=O)CC2(C)C1=O)c1c(F)cc(cc1F)C#Cc1ccccc1

InChI Key InChIKey=WNWMENKSNHQYCD-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402196   

TargetMetabotropic glutamate receptor 4(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM402196(US10011607, 29 | (9aRS)-7-[2,6-difluoro-4-(2- phen...)
Affinity DataEC50:  177nMAssay Description:A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent