BDBM402040 Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-methylacrylamido)phenylamino)pyrimidinyl-4-amino)propyl)-4-cyano-benzamide::US10011571, Example 7

SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C#N)n2)ccc1F

InChI Key InChIKey=ZHLODYGHLUYMDJ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 402040   

TargetTyrosine-protein kinase JAK3(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402040(US10011571, Example 7 | Preparation of N-(3-(5-chl...)
Affinity DataIC50: 11nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402040(US10011571, Example 7 | Preparation of N-(3-(5-chl...)
Affinity DataIC50: 105nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402040(US10011571, Example 7 | Preparation of N-(3-(5-chl...)
Affinity DataIC50: 1.40E+3nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402040(US10011571, Example 7 | Preparation of N-(3-(5-chl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402040(US10011571, Example 7 | Preparation of N-(3-(5-chl...)
Affinity DataIC50: 319nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Blk(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402040(US10011571, Example 7 | Preparation of N-(3-(5-chl...)
Affinity DataIC50: 286nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402040(US10011571, Example 7 | Preparation of N-(3-(5-chl...)
Affinity DataIC50: 162nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 1(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402040(US10011571, Example 7 | Preparation of N-(3-(5-chl...)
Affinity DataIC50: 698nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 3(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402040(US10011571, Example 7 | Preparation of N-(3-(5-chl...)
Affinity DataIC50: 107nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402040(US10011571, Example 7 | Preparation of N-(3-(5-chl...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402040(US10011571, Example 7 | Preparation of N-(3-(5-chl...)
Affinity DataIC50: 162nMAssay Description:Inhibition of human TBK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed