BDBM401867 2-{1-[(3R,6R)-6-Methyl-1-{[2- (trifluoromethoxy)phenyl]carbonyl} piperidin-3-yl]-1H-pyrazol-4- yl}propan-2-ol::US10010539, 83

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OC(F)(F)F)n1cc(cn1)C(C)(C)O

InChI Key InChIKey=OTTUFRVKDYSXOL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 401867   

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401867(US10010539, 83 | 2-{1-[(3R,6R)-6-Methyl-1-{[2- (tr...)
Affinity DataIC50: 31.4nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401867(US10010539, 83 | 2-{1-[(3R,6R)-6-Methyl-1-{[2- (tr...)
Affinity DataIC50: 1.00E+4nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent