BDBM401857 2-(5-Methyl-2-{(3R,6R)-6- methyl-1-[(2-phenylpyridin-3- yl)carbonyl]piperidin-3-yl}-2H- 1,2,3-triazol-4-yl)propan-2-ol::US10010539, 73

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1-c1ccccc1)n1nc(C)c(n1)C(C)(C)O

InChI Key InChIKey=BBGPHTNQCOBMGV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 401857   

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401857(US10010539, 73 | 2-(5-Methyl-2-{(3R,6R)-6- methyl-...)
Affinity DataIC50: 17.4nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401857(US10010539, 73 | 2-(5-Methyl-2-{(3R,6R)-6- methyl-...)
Affinity DataIC50: 2.46E+3nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent