BDBM401855 2-{5-Methyl-2-[(3R,6R)-6- methyl-1-{[2-(1H-pyrazol-1- yl)phenyl]carbonyl}piperidin-3- yl]-2H-1,2,3-triazol-4-yl}propan- 2-ol::US10010539, 71

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1cccn1)n1nc(C)c(n1)C(C)(C)O

InChI Key InChIKey=ZCZOKYNMWACIKW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 401855   

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401855(US10010539, 71 | 2-{5-Methyl-2-[(3R,6R)-6- methyl-...)
Affinity DataIC50: 9.30nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401855(US10010539, 71 | 2-{5-Methyl-2-[(3R,6R)-6- methyl-...)
Affinity DataIC50: 2.71E+3nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent