BDBM401817 2-{2-[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3- triazol-2-yl)thiophen-3- yl]carbonyl}piperidin-3-yl]-2H-1,2,3- triazol-4-yl}propan-2-ol::US10010539, 33

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-n1nccn1)n1ncc(n1)C(C)(C)O

InChI Key InChIKey=LNXJFYBVKGUBGB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 401817   

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401817(US10010539, 33 | 2-{2-[(3R,6R)-6-methyl-1-{[2-(2H-...)
Affinity DataIC50: 18.4nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401817(US10010539, 33 | 2-{2-[(3R,6R)-6-methyl-1-{[2-(2H-...)
Affinity DataIC50: 2.56E+3nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent