BDBM401798 ((2R,5R)-5-(4-(2-Hydroxypropan-2-yl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)(2-isopro-poxypyridin-3-yl)methanone ::US10010539, 15

SMILES CC(C)Oc1ncccc1C(=O)N1C[C@@H](CC[C@H]1C)n1ncc(n1)C(C)(C)O

InChI Key InChIKey=MABUFXSXRMFHNN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 401798   

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401798(US10010539, 15 | ((2R,5R)-5-(4-(2-Hydroxypropan-2-...)
Affinity DataIC50: 32.6nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401798(US10010539, 15 | ((2R,5R)-5-(4-(2-Hydroxypropan-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent