BDBM400912 2-Amino-N-{5-methyl-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(trifluoromethyl)-furo[3,2-b]pyridine-3-carboxamide::US10000507, Example 79

SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1c(C)cncc1NC(=O)c1c(N)oc2cc(cnc12)C(F)(F)F

InChI Key InChIKey=VFZCJJQOPREAAB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 400912   

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent
LigandPNGBDBM400912(US10000507, Example 79 | 2-Amino-N-{5-methyl-4-[(3...)
Affinity DataIC50: 10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent
LigandPNGBDBM400912(US10000507, Example 79 | 2-Amino-N-{5-methyl-4-[(3...)
Affinity DataIC50: 10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandPNGBDBM400912(US10000507, Example 79 | 2-Amino-N-{5-methyl-4-[(3...)
Affinity DataIC50: 55nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent