BDBM400331 US9999624, 2

SMILES COc1cnc(cn1)C(=O)Nc1cccc(c1)[C@]12CN(C[C@H]1CSC(N)=N2)c1ncc(F)cn1

InChI Key InChIKey=ULOIDZYMPRJOHF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 400331   

TargetBeta-secretase 1(Human)
Eli Lilly

US Patent
LigandPNGBDBM400331(US9999624, 2)
Affinity DataIC50: 0.482nMAssay Description:Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20× in KH2PO4 buffer. Ten μL of each dilution ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Eli Lilly

US Patent
LigandPNGBDBM400331(US9999624, 2)
Affinity DataIC50: 0.482nMAssay Description:Inhibition of human BACE1 (1 to 460 residues) expressed in HEK293 cells after 16 to 24 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed