BDBM400070 (R)-7-(2-((3,3-difluoro-1-(1H-1,2,3-triazol-4-yl)cyclobutyl)amino)-2-oxoacetyl)-2-fluoro-N-(4-fluorophenyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-5-carboxamide ::US10328053, Compound 48::US20230270719, Compound 48

SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2C[C@@H](F)Cn2c1C(=O)Nc1ccc(F)cc1

InChI Key InChIKey=LTPZSOKIZLBHDP-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 400070   

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandPNGBDBM400070(US10328053, Compound 48 | (R)-7-(2-((3,3-difluoro-...)
Affinity DataEC50:  6.5nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
Go to US Patent

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandPNGBDBM400070(US10328053, Compound 48 | (R)-7-(2-((3,3-difluoro-...)
Affinity DataEC50:  6.5nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
Go to US Patent