BDBM400050 N-(3-chloro-4-fluorophenyl)-7-(2-((3,3-difluoro-1-(6-(methylsulfonyl)-2,6-diazaspiro[3.3]heptane-2-carbonyl)cyclobutyl)amino)-2-oxoacetyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-5-carboxamide ::US10328053, Compound 28::US20230270719, Compound 28

SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)C(=O)N2CC3(C2)CN(C3)S(C)(=O)=O)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1

InChI Key InChIKey=FISUJQQTHIZFSL-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 400050   

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandPNGBDBM400050(US10328053, Compound 28 | N-(3-chloro-4-fluorophen...)
Affinity DataEC50:  112nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
Go to US Patent

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandPNGBDBM400050(US10328053, Compound 28 | N-(3-chloro-4-fluorophen...)
Affinity DataEC50:  112nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
Go to US Patent