BDBM400031 7-(2-((1-((2-oxa-6-azaspiro[3.3]heptan-6-yl)methyl)-3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-N-(3-chloro-4-fluorophenyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-5-carboxamide ::US10328053, Compound 10::US10874640, Compound 10::US20230270719, Compound 10

SMILES Cc1c(C(=O)C(=O)NC2(CN3CC4(COC4)C3)CC(F)(F)C2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1

InChI Key InChIKey=BKIRECDNYAVAGP-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 400031   

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandPNGBDBM400031(US10328053, Compound 10 | 7-(2-((1-((2-oxa-6-azasp...)
Affinity DataEC50:  56.1nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
Go to US Patent

TargetCapsid protein(HBV-C)
Gilead Sciences

US Patent
LigandPNGBDBM400031(US10328053, Compound 10 | 7-(2-((1-((2-oxa-6-azasp...)
Affinity DataEC50:  56.1nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandPNGBDBM400031(US10328053, Compound 10 | 7-(2-((1-((2-oxa-6-azasp...)
Affinity DataEC50:  56.1nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
Go to US Patent