BDBM399927 (6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl-6-fluoro-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide ::US10323042, Example 7::US10738063, Example 7

SMILES F[C@@H]1COc2c(c(nn2C1)C(=O)NC1CC1)-c1cc(F)c(Cl)cc1F

InChI Key InChIKey=QMOPFHQOZKALTC-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 399927   

LigandPNGBDBM399927(US10323042, Example 7 | (6S)-3-(4-Chloro-2,5-diflu...)
Affinity DataIC50: 6.51nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
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LigandPNGBDBM399927(US10323042, Example 7 | (6S)-3-(4-Chloro-2,5-diflu...)
Affinity DataIC50: 2nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
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LigandPNGBDBM399927(US10323042, Example 7 | (6S)-3-(4-Chloro-2,5-diflu...)
Affinity DataIC50: 31.4nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
Go to US Patent

LigandPNGBDBM399927(US10323042, Example 7 | (6S)-3-(4-Chloro-2,5-diflu...)
Affinity DataIC50: 306nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
Go to US Patent

LigandPNGBDBM399927(US10323042, Example 7 | (6S)-3-(4-Chloro-2,5-diflu...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of full length human PDE4B1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399927(US10323042, Example 7 | (6S)-3-(4-Chloro-2,5-diflu...)
Affinity DataIC50: 306nMAssay Description:Inhibition of full length human PDE4D3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
LigandPNGBDBM399927(US10323042, Example 7 | (6S)-3-(4-Chloro-2,5-diflu...)
Affinity DataIC50: 31nMAssay Description:Inhibition of full length human PDE4C1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399927(US10323042, Example 7 | (6S)-3-(4-Chloro-2,5-diflu...)
Affinity DataIC50: 2nMAssay Description:Inhibition of full length human PDE4A3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
LigandPNGBDBM399927(US10323042, Example 7 | (6S)-3-(4-Chloro-2,5-diflu...)
Affinity DataIC50: 6.51nMAssay Description:Human PDE4B1 coding sequence (amino acids 122 to 736 from the sequence with accession number Q07343) with the mutations resulting in the amino acid s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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LigandPNGBDBM399927(US10323042, Example 7 | (6S)-3-(4-Chloro-2,5-diflu...)
Affinity DataIC50: 2nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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LigandPNGBDBM399927(US10323042, Example 7 | (6S)-3-(4-Chloro-2,5-diflu...)
Affinity DataIC50: 31.4nMAssay Description:Human PDE4C1 coding sequence (amino acids 2 to 712 from the sequence with accession number NP_000914.2) was cloned into the baculovirus expression ve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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LigandPNGBDBM399927(US10323042, Example 7 | (6S)-3-(4-Chloro-2,5-diflu...)
Affinity DataIC50: 306nMAssay Description:A portion of the human PDE4D3 coding sequence (amino acids 50 to 672 from the sequence with accession number Q08499-2) was cloned into the baculoviru...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent