BDBM399186 US10323023, Compound TDI01250::US11390609, Compound TDI01250

SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1ccc2cc([nH]c2c1)C(=O)Nc1ccnnc1

InChI Key InChIKey=IXLKJDOEKCNYGP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 399186   

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM399186(US10323023, Compound TDI01250 | US11390609, Compou...)
Affinity DataIC50: 208nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2 [1-119](Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM399186(US10323023, Compound TDI01250 | US11390609, Compou...)
Affinity DataIC50: 208nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM399186(US10323023, Compound TDI01250 | US11390609, Compou...)
Affinity DataIC50: 1.00E+4nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM399186(US10323023, Compound TDI01250 | US11390609, Compou...)
Affinity DataIC50: 208nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent