BDBM398807 1-(3-(1,1-difluoro-2- hydroxyethyl)-4-methyl-1- phenyl-1H-pyrazol-5-yl)-3- ((3S,4R)-4-(4-fluorophenyl)-1- (2-methoxyethyl)pyrrolidin-3- yl)urea::US10323022, Example 284

SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)C(F)(F)CO)[C@@H](C1)c1ccc(F)cc1

InChI Key InChIKey=JDSVSMXUJBMGDV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 398807   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandPNGBDBM398807(1-(3-(1,1-difluoro-2- hydroxyethyl)-4-methyl-1- ph...)
Affinity DataIC50: 100nMAssay Description:Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent