BDBM398206 Preparations of 4-chloro-N-(((1R,3R)-1-hydroxy-3-methylcyclohexyl) methyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-indole-3-carboxamide::US10323000, Compound 143::US10676433, Compound 143
SMILES C[C@@H]1CCC[C@](O)(CNC(=O)c2cn(CC3CCCO3)c3cccc(Cl)c23)C1
InChI Key InChIKey=BBQGQUYUBIGQSH-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 398206
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 by fluorescence plate reader analysisMore data for this Ligand-Target Pair