BDBM397760 (S)-N-(5-(6-cyano-5-((1-(dimethylamino)-1-oxopropan-2-yl)amino)pyridin-3-yl)pyrazin-2-yl)cyclopropanecarboxamide::US9994547, Example 129::US9994547, Example 135

SMILES C[C@H](Nc1cc(cnc1C#N)-c1cnc(NC(=O)C2CC2)cn1)C(=O)N(C)C

InChI Key InChIKey=FVYYHMCSFFZPKR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 397760   

TargetSerine/threonine-protein kinase TBK1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM397760(US9994547, Example 129 | US9994547, Example 135 | ...)
Affinity DataIC50: 25.1nMAssay Description:TBK1 inhibition is determined using a 384 well μlate format in buffer containing 20 mM Hepes, pH 7.4, 10 mM MgCl2, 1 mM EDTA, 0.01% Brij-L23, 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM397760(US9994547, Example 129 | US9994547, Example 135 | ...)
Affinity DataIC50: 20nMAssay Description:TBK1 inhibition is determined using a 384 well μlate format in buffer containing 20 mM Hepes, pH 7.4, 10 mM MgCl2, 1 mM EDTA, 0.01% Brij-L23, 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details
Go to US Patent