BDBM397547 US10676457, Example 46::US11155532, Example 46::US9994546, Example 46::[1-(2-Fluorobenzoyl)-3-(4-{[(trans-2-phenylcyclopropyl)amino]methyl}piperidin-1-yl)azetidin-3-yl]acetonitrile

SMILES Fc1ccccc1C(=O)N1CC(CC#N)(C1)N1CCC(CNC2CC2c2ccccc2)CC1

InChI Key InChIKey=XEDHJJBMYHJZND-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 397547   

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM397547(US9994546, Example 46 | [1-(2-Fluorobenzoyl)-3-(4-...)
Affinity DataIC50: 30nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM397547(US9994546, Example 46 | [1-(2-Fluorobenzoyl)-3-(4-...)
Affinity DataIC50: 100nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM397547(US9994546, Example 46 | [1-(2-Fluorobenzoyl)-3-(4-...)
Affinity DataIC50: 100nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent