BDBM397191 US10596172, Compound I-128::US10828300, Compound I-128::US11351168, Compound I-128::US9987276, Compound I-128

SMILES CC(=O)c1cnc(Nc2ccc(OCCO)nc2)nc1Nc1ccc2OCCN(C(=O)C=C)c2c1

InChI Key InChIKey=BFVOWUMSASLJQP-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 397191   

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Celgene Car

US Patent
LigandPNGBDBM397191(US9987276, Compound I-128 | US10596172, Compound I...)
Affinity DataIC50: 10nMAssay Description:BMX: The activity of selected compounds of this invention in the BMX inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Celgene Car

US Patent
LigandPNGBDBM397191(US9987276, Compound I-128 | US10596172, Compound I...)
Affinity DataIC50: 55nMAssay Description:EGFR (WT) and EGFR (T790M/L858R): The Omnia Assay Protocol for potency assessment against EGFR is performed as described in Example 251 above except ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Celgene Car

US Patent
LigandPNGBDBM397191(US9987276, Compound I-128 | US10596172, Compound I...)
Affinity DataIC50: 10nMAssay Description:ITK: This example describes continuous-read kinase assays to measure inherent potency of compound against active forms of ITK enzymes as described in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Celgene Car

US Patent
LigandPNGBDBM397191(US9987276, Compound I-128 | US10596172, Compound I...)
Affinity DataIC50: 10nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Celgene Car

US Patent
LigandPNGBDBM397191(US9987276, Compound I-128 | US10596172, Compound I...)
Affinity DataIC50: 10nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Celgene Car

US Patent
LigandPNGBDBM397191(US9987276, Compound I-128 | US10596172, Compound I...)
Affinity DataIC50: 10nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Celgene Car

US Patent
LigandPNGBDBM397191(US9987276, Compound I-128 | US10596172, Compound I...)
Affinity DataIC50: 55nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Celgene Car

US Patent
LigandPNGBDBM397191(US9987276, Compound I-128 | US10596172, Compound I...)
Affinity DataIC50: 10nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Celgene Car

US Patent
LigandPNGBDBM397191(US9987276, Compound I-128 | US10596172, Compound I...)
Affinity DataIC50: 100nMAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Celgene Car

US Patent
LigandPNGBDBM397191(US9987276, Compound I-128 | US10596172, Compound I...)
Affinity DataIC50: 100nMAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Celgene Car

US Patent
LigandPNGBDBM397191(US9987276, Compound I-128 | US10596172, Compound I...)
Affinity DataIC50: 100nMAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Celgene Car

US Patent
LigandPNGBDBM397191(US9987276, Compound I-128 | US10596172, Compound I...)
Affinity DataIC50: 550nMAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent