BDBM397181 US11351168, Compound I-116::US9987276, Compound I-116

SMILES CS(=O)(=O)CCCOc1cccc(Nc2ncc(F)c(Oc3cccc(NC(=O)C=C)c3)n2)c1

InChI Key InChIKey=IGUOAKJBIDHVRK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 397181   

TargetEpidermal growth factor receptor(Human)
Celgene Car

US Patent
LigandPNGBDBM397181(US9987276, Compound I-116 | US11351168, Compound I...)
Affinity DataIC50: 10nMAssay Description:EGFR (WT) and EGFR (T790M/L858R): The Omnia Assay Protocol for potency assessment against EGFR is performed as described in Example 251 above except ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details
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TargetTyrosine-protein kinase ITK/TSK(Human)
Celgene Car

US Patent
LigandPNGBDBM397181(US9987276, Compound I-116 | US11351168, Compound I...)
Affinity DataIC50: 10nMAssay Description:ITK: This example describes continuous-read kinase assays to measure inherent potency of compound against active forms of ITK enzymes as described in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Celgene Car

US Patent
LigandPNGBDBM397181(US9987276, Compound I-116 | US11351168, Compound I...)
Affinity DataIC50: 100nMAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Celgene Car

US Patent
LigandPNGBDBM397181(US9987276, Compound I-116 | US11351168, Compound I...)
Affinity DataIC50: 100nMAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Celgene Car

US Patent
LigandPNGBDBM397181(US9987276, Compound I-116 | US11351168, Compound I...)
Affinity DataIC50: 100nMAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent