BDBM397115 N-(1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-(5-phenyl-2-pyridine-1-yl)-3-pyridinecarboxamide::US10456385, Example 7::US9987259, Example 7

SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ccc(cn1)-c1ccccc1

InChI Key InChIKey=ZRBJUENKXDKJCW-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 397115   

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Sk Biopharmaceuticals

US Patent
LigandPNGBDBM397115(US9987259, Example 7 | N-(1-azabicyclo[2.2.2]octan...)
Affinity DataEC50:  300nMAssay Description:On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details
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TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Sk Biopharmaceuticals

US Patent
LigandPNGBDBM397115(US9987259, Example 7 | N-(1-azabicyclo[2.2.2]octan...)
Affinity DataEC50:  300nMAssay Description:Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent