BDBM397098 2-(2-{5-[(2- cyclobutylphenyl)carbonyl] hexahydropyrrolo[3,4-c] pyrrol-2(1H)-yl}-5-methyl-1,3- oxazol-4-yl)propan-2-ol::US9987255, 12

SMILES Cc1oc(nc1C(C)(C)O)N1CC2CN(CC2C1)C(=O)c1ccccc1C1CCC1

InChI Key InChIKey=XFCVHBDMAHGRFG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 397098   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM397098(US9987255, 12 | 2-(2-{5-[(2- cyclobutylphenyl)carb...)
Affinity DataIC50: 23nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM397098(US9987255, 12 | 2-(2-{5-[(2- cyclobutylphenyl)carb...)
Affinity DataIC50: 5.30E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2020
Entry Details
Go to US Patent