BDBM395955 US10308660, Example 31::US12053470, Compound 32

SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(N)c(Sc3cccc(N)c3C(F)(F)F)c(=O)n2C)[C@@H]1N

InChI Key InChIKey=FWLRJXKKWWAIIU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 395955   

LigandPNGBDBM395955(US10308660, Example 31 | US12053470, Compound 32)
Affinity DataIC50: 20nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

LigandPNGBDBM395955(US10308660, Example 31 | US12053470, Compound 32)
Affinity DataIC50: 20nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent