BDBM395944 US10308660, Example 20::US12053470, Compound 30

SMILES COc1cccc(Sc2c(N)nc(N3CCC4(CO[C@@H](C)[C@H]4N)CC3)n(C)c2=O)c1Cl

InChI Key InChIKey=YQIKHFKYMKSZMC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 395944   

LigandPNGBDBM395944(US10308660, Example 20 | US12053470, Compound 30)
Affinity DataIC50: 17nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
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LigandPNGBDBM395944(US10308660, Example 20 | US12053470, Compound 30)
Affinity DataIC50: 17nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent