BDBM395725 Cis-(6R,9R)-9-(2-(difluoromethoxy)phenyl)-2-(4-(2-hydroxypropan-2-yl)phenyl)-6,7,8,9-tetrahydropyrido[4′,3′:4,5]imidazo[1,2-b]pyridazin-6-ol::US10308652, Example 6

SMILES CC(C)(O)c1ccc(cc1)-c1ccc2nc3[C@H](O)CN[C@@H](c3n2n1)c1ccccc1OC(F)F

InChI Key InChIKey=FZQQHPGRNQKJSY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 395725   

TargetTumor necrosis factor(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM395725(Cis-(6R,9R)-9-(2-(difluoromethoxy)phenyl)-2-(4-(2-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds serially diluted in DMSO were plated in an assay plate (Labcyte, Cat. #LP-0200) at final concentrations ranging from 0.004 μM to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent