BDBM395545 (R)-1-((2-(2'-chloro-3'-(5-((R)-2- hydroxypropyl)-1-methyl-4,5,6,7- tetrahydro-1H-imidazo[4,5- c]pyridine-2-carboxamido)-2- methylbiphenyl-3-yl)-7- cyanobenzo[d]oxazol-5-yl)methyl)-3- methylpyrrolidine-3-carboxylic acid::US10308644, Example 157::US10800768, Example 157::US11339149, Example 157

SMILES C[C@@H](O)CN1CCc2c(C1)nc(C(=O)Nc1cccc(c1Cl)-c1cccc(-c3nc4cc(CN5CC[C@](C)(C5)C(O)=O)cc(C#N)c4o3)c1C)n2C

InChI Key InChIKey=ONEXMUAEIZQYJD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 395545   

LigandPNGBDBM395545(US10308644, Example 157 | (R)-1-((2-(2'-chloro-3'-...)
Affinity DataIC50: 10nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 uL. Inhibitors were first serially diluted in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
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LigandPNGBDBM395545(US10308644, Example 157 | (R)-1-((2-(2'-chloro-3'-...)
Affinity DataIC50: 3.00E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
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TargetProgrammed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM395545(US10308644, Example 157 | (R)-1-((2-(2'-chloro-3'-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM395545(US10308644, Example 157 | (R)-1-((2-(2'-chloro-3'-...)
Affinity DataIC50: 10nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
Go to US Patent