BDBM395287 N-[6-(Hydroxymethyl)-2-(2-methoxyethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide::US10308634, Example 2::US10793545, Example 2::US11992481, Example 2::US12006303, Example 2

SMILES COCCn1cc2cc(NC(=O)c3cccc(n3)C(F)(F)F)c(CO)cc2n1

InChI Key InChIKey=ZNGQNAHACQRGPL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 395287   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395287(N-[6-(Hydroxymethyl)-2-(2-methoxyethyl)-2H-indazol...)
Affinity DataIC50: 136nMAssay Description:For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM DMSO solution of the test substance. 50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395287(N-[6-(Hydroxymethyl)-2-(2-methoxyethyl)-2H-indazol...)
Affinity DataIC50: 136nMAssay Description:For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM DMSO solution of the test substance. 50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395287(N-[6-(Hydroxymethyl)-2-(2-methoxyethyl)-2H-indazol...)
Affinity DataIC50: 136nMAssay Description:For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM solution of the test substance in DMSO....More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395287(N-[6-(Hydroxymethyl)-2-(2-methoxyethyl)-2H-indazol...)
Affinity DataIC50: 136nMAssay Description:The IRAK4-inhibitory activity of the inventive substances was measured in the IRAK4 TR-FRET assay (TR-FRET=Time Resolved Fluorescence Resonance Energ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2024
Entry Details
Go to US Patent