BDBM395272 (1S,2S)-2-Fluoro-N-4-[[(4aS,5aS) or (4aR,5aR)]-5a-methyl-4-oxo-3-(phenylamino)-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indol-2-yl]pyridin-2-ylcyclopropanecarboxamide::US10308629, Example 36::US10308629, Example 37

SMILES C[C@@]12C[C@@H]1C(=O)c1c(C2)[nH]c(c1Nc1ccccc1)-c1ccnc(NC(=O)[C@@H]2C[C@@H]2F)c1

InChI Key InChIKey=VBBBNOSMYHTKAN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 395272   

TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395272(US10308629, Example 36 | (1S,2S)-2-Fluoro-N-4-[[(4...)
Affinity DataIC50: 16nMAssay Description:Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM395272(US10308629, Example 36 | (1S,2S)-2-Fluoro-N-4-[[(4...)
Affinity DataIC50: 11nMAssay Description:Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent