BDBM395110 US10308615, Example 121::{2-[(2- phenylpropan-2- yl)amino]pyrimidin- 5-yl}[3- (trifluoromethyl) phenyl]methanone

SMILES CC(C)(Nc1ncc(cn1)C(=O)c1cccc(c1)C(F)(F)F)c1ccccc1

InChI Key InChIKey=VPQSHZNXENRMQC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 395110   

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM395110(US10308615, Example 121 | {2-[(2- phenylpropan-2- ...)
Affinity DataIC50: 32.3nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM395110(US10308615, Example 121 | {2-[(2- phenylpropan-2- ...)
Affinity DataIC50: 50.4nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM395110(US10308615, Example 121 | {2-[(2- phenylpropan-2- ...)
Affinity DataIC50: 9.10nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent