BDBM394677 3-({2-[(2- chlorobenzyl) amino]pyrimidin-5- yl}carbonyl) benzonitrile::US10308615, Example 32

SMILES Clc1ccccc1CNc1ncc(cn1)C(=O)c1cccc(c1)C#N

InChI Key InChIKey=OCMGSBSWBHCTCX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 394677   

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394677(US10308615, Example 32 | 3-({2-[(2- chlorobenzyl) ...)
Affinity DataIC50: 95.3nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394677(US10308615, Example 32 | 3-({2-[(2- chlorobenzyl) ...)
Affinity DataIC50: 71.3nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394677(US10308615, Example 32 | 3-({2-[(2- chlorobenzyl) ...)
Affinity DataIC50: 14.3nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent