BDBM394673 3-({2-[(4- chlorobenzyl)amino] pyrimidin-5- yl}carbonyl) benzonitrile::US10308615, Example 28

SMILES Clc1ccc(CNc2ncc(cn2)C(=O)c2cccc(c2)C#N)cc1

InChI Key InChIKey=VTBSCCAXSPGIKU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 394673   

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394673(US10308615, Example 28 | 3-({2-[(4- chlorobenzyl)a...)
Affinity DataIC50: 38.2nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394673(US10308615, Example 28 | 3-({2-[(4- chlorobenzyl)a...)
Affinity DataIC50: 21.8nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394673(US10308615, Example 28 | 3-({2-[(4- chlorobenzyl)a...)
Affinity DataIC50: 8.40nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent