BDBM394672 3-{[2- (benzylamino) pyrimidin-5- yl]carbonyl} benzonitrile::US10308615, Example 27

SMILES O=C(c1cccc(c1)C#N)c1cnc(NCc2ccccc2)nc1

InChI Key InChIKey=RXWGCAHYHQFVJH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 394672   

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394672(US10308615, Example 27 | 3-{[2- (benzylamino) pyri...)
Affinity DataIC50: 79.7nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394672(US10308615, Example 27 | 3-{[2- (benzylamino) pyri...)
Affinity DataIC50: 40.4nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394672(US10308615, Example 27 | 3-{[2- (benzylamino) pyri...)
Affinity DataIC50: 52.2nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394672(US10308615, Example 27 | 3-{[2- (benzylamino) pyri...)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed