BDBM394657 (3-methylphenyl){2-[(pyridin-3-ylmethyl)amino]pyrimidin-5-yl}methanone::US10308615, Example 14

SMILES Cc1cccc(c1)C(=O)c1cnc(NCc2cccnc2)nc1

InChI Key InChIKey=QUFWCLLJSUHQDF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 394657   

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394657(US10308615, Example 14 | (3-methylphenyl){2-[(pyri...)
Affinity DataIC50: 47.8nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394657(US10308615, Example 14 | (3-methylphenyl){2-[(pyri...)
Affinity DataIC50: 31.5nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394657(US10308615, Example 14 | (3-methylphenyl){2-[(pyri...)
Affinity DataIC50: 13nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM394657(US10308615, Example 14 | (3-methylphenyl){2-[(pyri...)
Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed