BDBM394434 2-(6-amino-5-(pyrrolidin-::US10308614, Example 35

SMILES Nc1nnc(cc1N1CCCC1)-c1ccccc1O

InChI Key InChIKey=TWJZDPRYXHWSDF-UHFFFAOYSA-N

Data  2 IC50  4 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 394434   

TargetTranscription activator BRG1 [1448-1575](Human)
Genentech

US Patent
LigandPNGBDBM394434(US10308614, Example 35 | 2-(6-amino-5-(pyrrolidin-)
Affinity DataIC50: 64.4nMAssay Description:His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvprgsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNAQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetProtein polybromo-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394434(US10308614, Example 35 | 2-(6-amino-5-(pyrrolidin-)
Affinity DataKd:  6nMAssay Description:Binding affinity to PBRM1 bromodomain 5 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein polybromo-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394434(US10308614, Example 35 | 2-(6-amino-5-(pyrrolidin-)
Affinity DataKd:  145nMAssay Description:Binding affinity to PBRM1 bromodomain 2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM394434(US10308614, Example 35 | 2-(6-amino-5-(pyrrolidin-)
Affinity DataKd:  2nMAssay Description:Binding affinity to SMARCA2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTranscription activator BRG1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394434(US10308614, Example 35 | 2-(6-amino-5-(pyrrolidin-)
Affinity DataKd:  6nMAssay Description:Binding affinity to SMARCA4 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM394434(US10308614, Example 35 | 2-(6-amino-5-(pyrrolidin-)
Affinity DataIC50: 2.60E+3nMAssay Description:Binding affinity to PXR (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394434(US10308614, Example 35 | 2-(6-amino-5-(pyrrolidin-)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to LXR alpha (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetOxysterols receptor LXR-beta(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394434(US10308614, Example 35 | 2-(6-amino-5-(pyrrolidin-)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to LXRbeta (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed