BDBM394405 (S)-2-(6-amino-5-(2-::US10308614, Example 6

SMILES C[C@H]1CCCCN1c1cc(nnc1N)-c1ccccc1O

InChI Key InChIKey=KXXHZDPNIIOTSH-UHFFFAOYSA-N

Data  2 IC50  4 Kd  10 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 394405   

TargetTranscription activator BRG1 [1448-1575](Human)
Genentech

US Patent
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataIC50: 84.6nMAssay Description:His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvprgsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNAQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetProtein polybromo-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataKd:  40nMAssay Description:Binding affinity to PBRM1 bromodomain 5 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein polybromo-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataKd:  5nMAssay Description:Binding affinity to PBRM1 bromodomain 2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataKd:  20nMAssay Description:Binding affinity to SMARCA2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTranscription activator BRG1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataKd:  40nMAssay Description:Binding affinity to SMARCA4 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataIC50: 1.60E+3nMAssay Description:Binding affinity to PXR (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataEC50:  4.80E+3nMAssay Description:Agonist activity at PXR (unknown origin) by cellular reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to LXR alpha (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetOxysterols receptor LXR-beta(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataEC50:  300nMAssay Description:Binding affinity to LXRbeta (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to RXR alpha (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to CAR (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataEC50: >2.00E+4nMAssay Description:Binding affinity to PPAR alpha (unknown origin) by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at PPAR delta in GeneBLAzer PPARdelta-UAS-bla HEK 293T cells preincubated with compound for 16 to 24 hrs followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at PPAR gamma in GeneBLAzer PPARgamma-UAS-bla HEK 293H cells preincubated with compound for 16 to 24 hrs followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataEC50:  8.20E+3nMAssay Description:Agonist activity at LXRalpha in GeneBLAzer LXRalpha-UAS-bla HEK 293T cells preincubated with compound for 16 to 24 hrs followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetOxysterols receptor LXR-beta(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at LXRbeta in GeneBLAzer LXRbeta-UAS-bla HEK 293T cells preincubated with compound for 16 to 24 hrs followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed