BDBM394286 US10428087, Example 5::US10829502, Example 5::US11401280, Example 5::US9975907, Example 5

SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cc(F)cc(F)c1

InChI Key InChIKey=GDGASKUEJYOWFV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 394286   

LigandPNGBDBM394286(US9975907, Example 5 | US10428087, Example 5 | US1...)
Affinity DataIC50: 300nMAssay Description:PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
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LigandPNGBDBM394286(US9975907, Example 5 | US10428087, Example 5 | US1...)
Affinity DataIC50: 75nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
Go to US Patent

LigandPNGBDBM394286(US9975907, Example 5 | US10428087, Example 5 | US1...)
Affinity DataIC50: 300nMAssay Description:Assay A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were fir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent

LigandPNGBDBM394286(US9975907, Example 5 | US10428087, Example 5 | US1...)
Affinity DataIC50: 75nMAssay Description:Assay A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent

LigandPNGBDBM394286(US9975907, Example 5 | US10428087, Example 5 | US1...)
Affinity DataIC50: 300nMAssay Description:Example A1: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibitors were f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

LigandPNGBDBM394286(US9975907, Example 5 | US10428087, Example 5 | US1...)
Affinity DataIC50: 75nMAssay Description:Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

LigandPNGBDBM394286(US9975907, Example 5 | US10428087, Example 5 | US1...)
Affinity DataIC50: 300nMAssay Description:Assay A1 PI3Kδ: The kinase reaction was conducted in 384-well REMP plate from Thermo Fisher Scientific in a final volume of 40 μL. Inhibito...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent

LigandPNGBDBM394286(US9975907, Example 5 | US10428087, Example 5 | US1...)
Affinity DataIC50: 75nMAssay Description:PI3Kα, PI3Kβ, PI3Kγ: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent