BDBM394237 US9975882, Example 28

SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(F)c4)c3)c(C(N)=O)c2N)C1

InChI Key InChIKey=KOQJXUXLQGQJDF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 394237   

TargetTyrosine-protein kinase BTK(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM394237(US9975882, Example 28)
Affinity DataIC50: 0.300nMAssay Description:Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM394237(US9975882, Example 28)
Affinity DataIC50: 1.20nMAssay Description:Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
Go to US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM394237(US9975882, Example 28)
Affinity DataIC50: 56nMAssay Description:Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Tec(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM394237(US9975882, Example 28)
Affinity DataIC50: 39nMAssay Description:Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM394237(US9975882, Example 28)
Affinity DataIC50: 95nMAssay Description:Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
Go to US Patent