BDBM394123 US9975861, 3::US9975861, 4::US9975861, 5

SMILES CCNC1=NC(NC(=O)N1)c1ccc(F)cc1

InChI Key InChIKey=XWRLROSVVBGPPA-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 394123   

TargetBeta-secretase 1(Human)
Fondazione Istituto Itaiano Di Tecnologia

US Patent
LigandPNGBDBM394123(US9975861, 3 | US9975861, 5 | US9975861, 4)
Affinity DataIC50: 1.61E+4nMAssay Description:β-secretase (BACE-1, Sigma-Aldrich) inhibition studies were performed by employing a peptide mimicking APP sequence as substrate (Methoxycoumari...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Fondazione Istituto Itaiano Di Tecnologia

US Patent
LigandPNGBDBM394123(US9975861, 3 | US9975861, 5 | US9975861, 4)
Affinity DataIC50: 7.11E+3nMAssay Description:Human recombinant GSK-3β was purchased from Millipore (Millipore Iberica S.A.U.) The prephosphorylated polypeptide substrate was purchased from ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Fondazione Istituto Itaiano Di Tecnologia

US Patent
LigandPNGBDBM394123(US9975861, 3 | US9975861, 5 | US9975861, 4)
Affinity DataIC50: 8.13E+3nMAssay Description:β-secretase (BACE-1, Sigma-Aldrich) inhibition studies were performed by employing a peptide mimicking APP sequence as substrate (Methoxycoumari...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Fondazione Istituto Itaiano Di Tecnologia

US Patent
LigandPNGBDBM394123(US9975861, 3 | US9975861, 5 | US9975861, 4)
Affinity DataIC50: 1.26E+4nMAssay Description:Human recombinant GSK-3β was purchased from Millipore (Millipore Iberica S.A.U.) The prephosphorylated polypeptide substrate was purchased from ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Fondazione Istituto Itaiano Di Tecnologia

US Patent
LigandPNGBDBM394123(US9975861, 3 | US9975861, 5 | US9975861, 4)
Affinity DataIC50: 1.26E+4nMAssay Description:β-secretase (BACE-1, Sigma-Aldrich) inhibition studies were performed by employing a peptide mimicking APP sequence as substrate (Methoxycoumari...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Fondazione Istituto Itaiano Di Tecnologia

US Patent
LigandPNGBDBM394123(US9975861, 3 | US9975861, 5 | US9975861, 4)
Affinity DataIC50: 1.57E+4nMAssay Description:Human recombinant GSK-3β was purchased from Millipore (Millipore Iberica S.A.U.) The prephosphorylated polypeptide substrate was purchased from ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Fondazione Istituto Itaiano Di Tecnologia

US Patent
LigandPNGBDBM394123(US9975861, 3 | US9975861, 5 | US9975861, 4)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of C-terminal His-tagged recombinant human BACE-1 expressed in mouse NSO cells using methoxy coumarin Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Fondazione Istituto Itaiano Di Tecnologia

US Patent
LigandPNGBDBM394123(US9975861, 3 | US9975861, 5 | US9975861, 4)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human recombinant GSK3beta using prephosphorylated polypeptide GSM as substrate incubated for 30 mins in presence of ATP by Kinase-Glo ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Fondazione Istituto Itaiano Di Tecnologia

US Patent
LigandPNGBDBM394123(US9975861, 3 | US9975861, 5 | US9975861, 4)
Affinity DataIC50: 1.61E+4nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Fondazione Istituto Itaiano Di Tecnologia

US Patent
LigandPNGBDBM394123(US9975861, 3 | US9975861, 5 | US9975861, 4)
Affinity DataIC50: 7.11E+3nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed