BDBM394064 2-fluoro-5-[4-({trans-4- [4- (methylsulfonyl)piperazin- 1- yl]cyclohexyl}amino) quinazolin-6-yl]pyridin-3-ol::US9969749, Example 5-14

SMILES CS(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc(F)c(O)c1

InChI Key InChIKey=NSDYWRLPHUNVJX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 394064   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394064(US9969749, Example 5-14 | 2-fluoro-5-[4-({trans-4-...)
Affinity DataIC50: 1nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent