BDBM393395 3-((3'-Methoxy-[1,1'-biphenyl]-4-yl)methoxy)-3-phenylazetidine-1-carbonitrile::US9963444, Example 96

SMILES COc1cccc(c1)-c1ccc(COC2(CN(C2)C#N)c2ccccc2)cc1

InChI Key InChIKey=ZTKDXCKBUCJMFZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 393395   

TargetN-acylethanolamine-hydrolyzing acid amidase(Human)
Northeastern University

US Patent
LigandPNGBDBM393395(US9963444, Example 96 | 3-((3'-Methoxy-[1,1'-biphe...)
Affinity DataIC50: 55nMAssay Description:In order to have an assay method more conducive to high-throughput screening than those published for measuring the NAE hydrolyzing activity of NAAA,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
Go to US Patent

TargetN-acylethanolamine-hydrolyzing acid amidase(Human)
Northeastern University

US Patent
LigandPNGBDBM393395(US9963444, Example 96 | 3-((3'-Methoxy-[1,1'-biphe...)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM393395(US9963444, Example 96 | 3-((3'-Methoxy-[1,1'-biphe...)
Affinity DataIC50: 61nMAssay Description:Inhibition of recombinant human FAAH expressed in Escherichia coli using fluorogenic AAMCA as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed