BDBM393394 US9963444, Example 95

SMILES COc1cccc(c1)-c1ccc(COC2(C)CN(C2)C#N)cc1

InChI Key InChIKey=XYFPPQFRZROGKN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 393394   

TargetN-acylethanolamine-hydrolyzing acid amidase(Human)
Northeastern University

US Patent
LigandPNGBDBM393394(US9963444, Example 95)
Affinity DataIC50: 55nMAssay Description:In order to have an assay method more conducive to high-throughput screening than those published for measuring the NAE hydrolyzing activity of NAAA,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
Go to US Patent

TargetN-acylethanolamine-hydrolyzing acid amidase(Human)
Northeastern University

US Patent
LigandPNGBDBM393394(US9963444, Example 95)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM393394(US9963444, Example 95)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of recombinant human FAAH expressed in Escherichia coli using fluorogenic AAMCA as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM393394(US9963444, Example 95)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of recombinant human hexaHis-tagged MGL expressed in Escherichia coli BL21 (DE3) using fluorogenic AHMMCE as substrate preincubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed