BDBM393289 US9963439, BMS961

SMILES CC1(CCC(c2c1ccc(c2)[C@H](C(=O)Nc3ccc(cc3F)C(=O)O)O)(C)C)C

InChI Key InChIKey=AANFHDFOMFRLLR-UHFFFAOYSA-N

Data  2 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 393289   

TargetCytochrome P450 26A1(Human)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM393289(US9963439, BMS961)
Affinity DataIC50: 1.48E+4nMAssay Description:Eighteen compounds were tested as potential inhibitors of CYP26A1 and CYP26B1. The formation of 9-cis-4-OH-RA metabolite was monitored and the percen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM393289(US9963439, BMS961)
Affinity DataIC50: 3.90E+4nMAssay Description:Compounds were assessed for inhibition (IC50, n=2) of CYP2C8, CYP2C9 and CYP3A4 in pooled human liver microsomes using selective probe substrates at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
Go to US Patent

TargetRetinoic acid receptor gamma(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM393289(US9963439, BMS961)
Affinity DataEC50:  51nMAssay Description:Agonist activity at GAL4 DNA-binding domain-tagged RARgamma (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor alpha(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM393289(US9963439, BMS961)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4 DNA-binding domain-tagged RARalpha (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetRetinoic acid receptor beta(Human)
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM393289(US9963439, BMS961)
Affinity DataEC50:  1.65E+3nMAssay Description:Agonist activity at GAL4 DNA-binding domain-tagged RARbeta (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)