BDBM392746 US10301305, Example 20::{1-[4-(1-Cyclohexyl-1H-benzimidazol-5-yl)-1H-imidazo[4,5-c]pyridin-6-yl]-4-hydroxymethyl-piperidin-4-yl}-methanol

SMILES OCC1(CO)CCN(CC1)c1cc2[nH]cnc2c(n1)-c1ccc2n(cnc2c1)C1CCCCC1

InChI Key InChIKey=HDXLHIPRXGLAGB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 392746   

TargetPutative glyoxylate/hydroxypyruvate reductase B(Staphylococcus aureus)
Mutabilis

US Patent
LigandPNGBDBM392746({1-[4-(1-Cyclohexyl-1H-benzimidazol-5-yl)-1H-imida...)
Affinity DataIC50: 12nMAssay Description:The assay buffer AB contained 50 mM Hepes pH8.0, 10 mM MgCl2, 50 mM KCl, 0.012% Triton-X100, 10 mM DTT and 100 nM Myelin-basic protein. The following...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent

TargetD-alanine--D-alanyl carrier protein ligase(Enterococcus faecalis (strain ATCC 700802 / V583))
Mutabilis

US Patent
LigandPNGBDBM392746({1-[4-(1-Cyclohexyl-1H-benzimidazol-5-yl)-1H-imida...)
Affinity DataIC50: 56nMAssay Description:The assay buffer AB contained 50 mM Hepes pH8.0, 10 mM MgCl2, 50 mM KCl, 0.012% Triton-X100, 10 mM DTT and 100 nM Myelin-basic protein. The following...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent

TargetD-alanine--D-alanyl carrier protein ligase(Enterococcus faecium E1679)
Mutabilis

US Patent
LigandPNGBDBM392746({1-[4-(1-Cyclohexyl-1H-benzimidazol-5-yl)-1H-imida...)
Affinity DataIC50: 170nMAssay Description:The assay buffer AB contained 50 mM Hepes pH8.0, 10 mM MgCl2, 50 mM KCl, 0.012% Triton-X100, 10 mM DTT and 100 nM Myelin-basic protein. The following...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent

TargetD-alanine--D-alanyl carrier protein ligase(Streptococcus agalactiae serotype V (strain ATCC B...)
Mutabilis

US Patent
LigandPNGBDBM392746({1-[4-(1-Cyclohexyl-1H-benzimidazol-5-yl)-1H-imida...)
Affinity DataIC50: 290nMAssay Description:The assay buffer AB contained 50 mM Hepes pH8.0, 10 mM MgCl2, 50 mM KCl, 0.012% Triton-X100, 10 mM DTT and 100 nM Myelin-basic protein. The following...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent